Tirapazamine - 抑制剂 - 陶素生化

来自 : www.tsbiochem.com/compound/Tir 发布时间：2021-03-24

体内活性

The increased the anticancer efficacy of tirapazamine combined with irinotecan was further validated in a human liver cancer Bel-7402 xenograft mouse model [1]. Rats were intraperitoneally injected six times once a week with tirapazamine in two doses, 5 (5TP) and 10 mg/kg (10TP), while doxorubicin was administered in dose 1.8 mg/kg (DOX). Subsequent two groups received both drugs simultaneously (5TP+DOX and 10TP+DOX). Tirapazamine reduced heart lipid peroxidation and normalized RyR2 protein level altered by doxorubicin [2].

Molecular cancer therapeutics, 2013: molcanther. 0490.2013. 2. Sliwinska J, Dudka J, Korga A, et al. Tirapazamine-Doxorubicin Interaction Referring to...Tirapazamine | SR259075 | Tirazone | SR4233 | 27314-97-2Tirapazamine-27314-97-2 | Tirapazamine is a potent cytotoxic agent under hypoxic conditions, can induce apoptosis by inducing breaks in single and double-stranded DNA, as well as chromosomal breaks. The compound sensitizes cells to other ionizing radiation and other cytotoxic agents like cisplatin.提供HPLC、LCMS、HNMR 质检严格，质量保证。Tirapazamine